Our laboratory primarily focused on normal cellular differentiation and its deregulation associated with the development of disease. Cellular differentiation is an essential process that reprograms primitive cells into tissue-specific cell lineage such as muscle, nerve, bone etc. A major challenge in this differentiation perspective is to understand the regulation of genome reprogramming that leads to the formation of specialized tissues within a multicellular organism. During cellular differentiation, genome undergoes a chromatin structure and nuclear organization in establishing a tissue-specific gene expression program in response to signals. In particular, the extrinsic signals conveyed through a cascade of cellular signaling pathway, which ultimately converge to alter the epigenome in directing the transcriptional activation/repression to establish the differentiation controlling gene expression program. This differentiation-specific alteration of epigenome is tightly controlled by tissue specific transcriptional factors for example MRFs (muscle), NGFs (nerve). These transcription factors collaborate with epigenetic modifiers such as histone methyltransferases (HMTs), histone demethylase (HDMs), histone acetyltransferases (HATs) and histone deacetylase (HDACs) in the execution of differentiation-specific gene expression program. Deregulation or abnormal differentiation program leads to diseased conditions like cancer and degenerative diseases (Muscular dystrophy, Alzheimer’s diseases etc). Therefore, understanding the epigenetic regulation in the establishment of differentiation program will benefit to identify the defects associated with diseases, which may have potential for the development of novel therapeutic strategies for the patients affected by these dreadful diseases.